- 5th edition was published during the life of Hahnemann, where as 6th edition was published 78 years after death of author
- 5th edition was translated from German to English by R.E. Dudgeon in 1833 where as the 6th edition was translated from German to English by Dr. William Boericke in 1921
- 5th edition is most popular than 6th edition because the new scale of potencies (50 millesimal) are still not well known or proved thoroughly by homoeopaths all over the world.
- 294 Aphorism in 5th edition, there are only 291 aphorism in 6th edition
- Several new foot notes were added in the 6th edition
- 5th edition, use vital force is use , where as vital principal and dynamic influence are used in 6th edition]
- There is no foot note on Dynamic influence in the 5th edition where as a long foot note appears an it in 6th edition (aphorism)
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ORGANON OF MEDICINE