Anatomy of Heart Sounds: A Complete Guide for Medical Students

1. What Are Heart Sounds?

  • Heart sounds are noises produced by the vibration of valves and blood flow during the cardiac cycle.
  • Best heard using a stethoscope.

2. Types of Heart Sounds

There are two normal (physiological) heart sounds and two extra (abnormal or sometimes normal) heart sounds:

Normal Heart Sounds:

  1. First Heart Sound (S₁) – “Lub
  2. Second Heart Sound (S₂) – “Dub

Additional Heart Sounds (may be normal or abnormal):

  1. Third Heart Sound (S₃)
  2. Fourth Heart Sound (S₄)

S₁ – First Heart Sound (Lub)

  • Due to closure of AV valves (Mitral and Tricuspid valves)
  • Occurs at the beginning of ventricular systole
  • Best heard at the apex of the heart
  • Low-pitched & long

Mnemonic: "M-T" (Mitral & Tricuspid closure = S₁)


S₂ – Second Heart Sound (Dub)

  • Due to closure of semilunar valves (Aortic and Pulmonary valves)
  • Occurs at the beginning of diastole
  • Best heard at the base of the heart
  • High-pitched & short

Mnemonic: "A-P" (Aortic & Pulmonary closure = S₂)


S₃ – Third Heart Sound

  • Due to rapid ventricular filling
  • Occurs just after S₂
  • Best heard in young individuals, athletes, and pregnancy (can be normal)
  • In older adults, may indicate heart failure

Mnemonic: "Kentucky" rhythm (S₁ - S₂ - S₃)


S₄ – Fourth Heart Sound

  • Due to atrial contraction against stiff ventricle
  • Occurs just before S₁
  • Always abnormal in adults – indicates LV hypertrophy, HTN

Mnemonic: "Tennessee" rhythm (S₄ - S₁ - S₂)


3. Auscultation Areas of the Heart

Valve Area

Location (Intercostal Space)

Aortic valve

Right 2nd ICS, just next to sternum

Pulmonary valve

Left 2nd ICS, next to sternum

Tricuspid valve

Left 4th or 5th ICS, near sternum

Mitral valve

Left 5th ICS, midclavicular line (apex)

4. Clinical Significance

  • Murmurs – due to turbulent blood flow or valve defects.
  • Splitting of S₂ – may be normal during inspiration or pathological.
  • Gallop rhythm – combination of S₁, S₂, and S₃/S₄ – indicates cardiac dysfunction.


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